Proliferative diabetic retinopathy as onset of type 1 diabetes

Age at Onset and the Risk of Proliferative Retinopathy in Type 1 Diabetes

OBJECTIVE Age at onset of type 1 diabetes influences the risk of microvascular complications. However, the long-term risk of proliferative retinopathy within the wide spectrum of age at onset of type 1 diabetes is less well known. RESEARCH DESIGN AND METHODS A sample of 1,117 consecutively recruited patients was drawn from the FinnDiane Study population (4,800 patients). Type 1 diabetes was d...

Development of proliferative diabetic retinopathy in African-Americans and whites with type 1 diabetes.

OBJECTIVE To investigate the comparable risk of developing proliferative diabetic retinopathy (PDR) in African-Americans and whites with type 1 diabetes. RESEARCH DESIGN AND METHODS Using a cohort design with the sample drawn from medical records, the sample consisted of 312 people with type 1 diabetes (97 African-Americans, 215 whites) having at least two visits to a Model Demonstration Unit...

Rosiglitazone and delayed onset of proliferative diabetic retinopathy.

OBJECTIVE To evaluate whether rosiglitazone maleate, an oral peroxisome-proliferating activated receptor gamma agonist and oral insulin sensitizing agent with potential antiangiogenic activity, delays onset of proliferative diabetic retinopathy (PDR). METHODS Longitudinal medical record review of all patients treated with rosiglitazone receiving both medical and ophthalmic care at the Joslin ...

Proliferative diabetic retinopathy.

Heritability of Proliferative Diabetic Retinopathy

OBJECTIVE Diabetic nephropathy clusters in families, suggesting that genetic factors play a role in its pathogenesis. We investigated whether similar clustering exists for proliferative retinopathy in families with two or more siblings with type 1 diabetes. RESEARCH DESIGN AND METHODS The FinnDiane Study has characterized 20% (4,800 patients) of adults with type 1 diabetes in Finland. In 188 ...